prof. dr. ir. Thas Olivier
Early detection of a change in the viral population in HIV-1 and HCV infected patients can substantially improve treatment
In a virology research environment, massively parallel sequencing (MPS) technologies provide the opportunity to study viral quasispecies in for instance HIV-1 and HCV-infected patients. This is essential for the understanding of resistance pathways and can substantially improve treatment. We have developed statistical methods that allow for more efficient data-analysis, allowing to detect variants present at frequencies as low as 0.5%.
Early detection of a change in the quasispecies viral population in HIV-1 and HCV infected patients can substantially improve treatment.